Publications
Publications
2024
Evergren E, Mills IG, Kennedy G. Adaptations of membrane trafficking in cancer and tumorigenesis. Journal of Cell Sciences 2024; 137(10): jcs260943. https://doi.org/10.1242/jcs.260943
Holloway J, Seeley A, Cobbe N, Turkington RC, Longley DB, Evergren E. The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis. Cell Death Disease 2024; 15: 40. https://rdcu.be/dvRnh
2023
Butler L.M., Evergren E. (2023) Ultrastructural analysis of prostate cancer tissue provides insights into androgen-dependent adaptations to membrane contact site establishment. Frontiers in Oncology, 12, https://doi.org/10.3389/fonc.2023.1217741.
Kennedy G., Gibson O., O’Hare D.T., Mills I.G., Evergren E. (2023) The role of CaMKK2 in Golgi-associated vesicle trafficking. Biochemical Society Transactions, https://doi.org/10.1042/BST20220833
CaMKK2 is involved in maintaining various physiological and cellular processes within the cell that regulate energy homeostasis and cell growth. Consequently, its deregulation has a role in multiple human metabolic diseases including obesity and cancer. Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications .
2022
Craig E.L., Stopsack K.H., Evergren E., Penn L.Z., Freedland S.J., Hamilton R.J., Allott E.H. (2022) Statins and prostate cancer—hype or hope? The epidemiological perspective. Prostate Cancer and Prostatic Disease, https://rdcu.be/cScOZ
Lin J, McCann AP, Burden R, Micu I, Williams R, Van Schaeybroeck, Evergren E, Mullan P, Simpson JC, Scott CJ, Burrows JF. (2022) USP17 is required for peripheral trafficking of lysosomes. EMBO Reports, e51932. https://doi.org/10.15252/embr.202051932
2021
Stewart, L. M., Gerner, L., Rettel, M., Stein, F., Burrows, J. F., Mills, I. G., & Evergren, E. (2021). CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation. Cell Death & Disease, 12(11), 1040. https://doi.org/10.1038/s41419-021-04335-x
Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zininos I, ., Dehairs, J., Burvenich, I. J. G., Zadra, G., Chetta, P., Bango C., Evergren E., Ryan NK., Gillis JL., Mah CY., Tieu T., Hanson AR., Carellu R., Blonch K., Panagopoulos V., Waelkens E., Derua R., Williams ED., Evdokioou A., Cifuentes-Rius A., Voelcker NH., Mills IG., Tilley WD., Scott AM., Loda M., Selth LA., Swinnen JV., Butler LM. (2021) ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer. Cancer Res. https://doi.org/10.1158/0008-5472.can-20-2511
2020
Bantval Rao R, Ramos-Montoya A, Scott H, Berry L, Reichelt S, Macarthur S, Russell R, Neal DE*, Evergen E*, Mills IG*. HIP1 mediates oncogenic transformation and cancer progression through STAT3 signalling. bioRxiv. doi: https://doi.org/10.1101/2020.07.09.191734. Peer reviewed & under revison in eLife. *These authors contributed equally to the work.
Khawaja H, Campbell A, Roberts JZ, Javadi A, O'Reilly P, McArt D, Allen WL., Majkut J., Rehm M., Bardelli A., Di Nicolantonio F., Scott CJ, Kennedy R, Vitale N, Harrison T, Sansom OJ, Longley DB, Evergren E, Van Schaeybroeck S. (2020) RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer. Cell Death Dis. 2020 Oct 29;11(10):930. https://doi.org/10.1038/s41419-020-03131-3
de la Vega Gallardo, N., Penalva, R., Dittmer, M., Naughton, M., Falconer, J., Moffat, J., Guzman de la Fuente, A., Romero Hombrebueno, J., Williams, A.C., Lin, Z., Perbal, B., Ingram, R.J., Evergren, E., Fitzgerald, D.C. (2020). Dynamic CCN3 expression in the murine CNS does not confer essential roles in (re)myelination. Proceedings of the National Academy of Sciences 117(30), 18018-18028. https://doi.org/10.1073/pnas.1922089117
Pechstein, A., Tomilin, N., Fredrich, K., Vorontsova, O., Sopova, E., Evergren, E., Haucke, V., Brodin, L. and Shupliakov, O. (2020). Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation. Cell Rep 30, 2594–2602.e3. https://doi.org/10.1016/j.celrep.2020.01.092
Roberts, J. Z., Holohan, C., Sessler, T., Fox, J., Crawford, N., Riley, J. S., Khawaja, H., Majkut, J., Evergren, E., Humphreys, L. M., Ferris, J., Higgins, C., Espona-Fiedler, M., Moynagh, P., McDade S.S., Longley, D.B. (2020). The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L). Cell Death Differ. 96, 245–16. https://doi.org/10.1038/s41418-020-0539-7
2019
Simunovic, M., Evergren, E., Callan-Jones, A. and Bassereau, P. (2019). Curving Cells Inside and Out: Roles of BAR Domain Proteins in Membrane Shaping and Its Cellular Implications. Annu. Rev. Cell Dev. Biol. 35, 111–129. https://doi.org/10.1146/annurev-cellbio-100617-060558
2018
Deevi, R. K., Javadi, A., McClements, J., Vohhodina, J., Savage, K., Loughrey, M. B., Evergren, E* and Campbell, F. C*. (2018) Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring. Journal of Pathology 244(4), 445-459. *joint senior authors https://doi.org/10.1002/path.5035
McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Schaeybroeck, S. V., Scott, C. J., & Burrows, J. F. (2018). USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells. Cell Communication and Signaling : CCS, 16(1), 77. https://doi.org/10.1186/s12964-018-0291-5
2017
Evergren, E.*, Cobbe, N. and McMahon, H. T. (2017). Eps15R and clathrin regulate EphB2-mediated cell repulsion. Traffic 17, 240. https://doi.org/10.1111/tra.12531 *corresponding author
Javdi A, Deevi RK, Evergren E, Tepaz E, Baillie G, Scott M, Campbell FC. (2017) PTEN controls glandular morphogenesis through a juxtamembrane b-arrestin-ARHGAP10 scaffolding complex. eLIFE 6, 1771. https://doi.org/10.7554/elife.24578
Simunovic M, Manneville JM, Renard HF, Evergren E, Raghunathan K, Kenworthy A, Voth GA, Prost J, McMahon HT, Johannes L, Bassereau P, Callan-Jones A, (2017) Friction-driven scission of membrane nanotubes scaffolded by BAR proteins. Cell 170, 172–184.e11. https://doi.org/10.1016/j.cell.2017.05.047
The paper was highlighted in Cell by Jim Hurley - “Friction at the BAR leads to membrane breakup”.
Dombrowski Y, O’Hagan T, Dittmer M, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Hassan R, Moffat J, Falconer J, Penalva R, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC, (2017) Regulatory T cells promote myelin regeneration in the Central Nervous System. Nature Neuroscience 20(5), 674-680. https://doi.org/10.1038/nn.4528
2016
Simunovic M, Evergren E, Golushko I, Prévost C, Renard HF, Johannes L, McMahon HT, Lorman V, Voth GA, Bassereau P. (2016) How curvature-generating proteins build scaffolds on membrane nanotubes. Proceedings of the National Academy of Sciences, 113(40), 11226–11231. https://doi.org/10.1073/pnas.1606943113
Wen, P. J., Grenklo, S., Arpino, G., Tan, X., Liao, H.-S., Heureaux, J., Peng, S.-Y., Chiang, H.-C., Hamid, E., Zhao, W.-D. Shin W, Näreoja T, Evergren E, Peng S-Y, Karlsson R, Ebert SN, Ervasti JM, Jin A, Liu AP, Shupliakov O, Wu L-G,. (2016) Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane. Nature Communications, 7, 12604. https://doi.org/10.1038/ncomms12604
Boucrot E, Pick A, Camdere G, Liska N, Evergren E, McMahon HT, Kozlov MM (2012) Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell 149, 124-136. https://doi.org/10.1016/j.cell.2012.01.047
Sundborger A, Soderblom C, Vorontsova O, Evergren E, Hinshaw JE & Shupliakov O (2011) An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling. J Cell Sci 124, 133-143. https://doi.org/10.1242/jcs.072686
Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R & McMahon HT (2010) FCHo proteins are nucleators of clathrin-mediated endocytosis. Science 328, 1281-1284. https://doi.org/10.1126/science.1188462
Owe SG, Jensen V, Evergren E, Ruiz A, Shupliakov O, Kullmann DM, Storm-Mathisen J, Walaas SI, Hvalby O & Bergersen LH (2009) Synapsin- and actin-dependent frequency enhancement in mouse hippocampal mossy fiber synapses. Cereb Cortex 19, 511-523. https://doi.org/10.1093/cercor/bhn101
Carlen M, Meletis K, Goritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabe-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O & Frisen J (2009) Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nature Neuroscience 12, 259-267. https://doi.org/10.1038/nn.2268
Meletis K, Barnabe-Heider F, Carlen M, Evergren E, Tomilin N, Shupliakov O & Frisen J (2008) Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol 6, e182. https://doi.org/10.1371/journal.pbio.0060182
Evergren E, Benfenati F & Shupliakov O (2007) The synapsin cycle: a view from the synaptic endocytic zone. J Neurosci Res 85, 2648-2656. https://doi.org/10.1002/jnr.21176
Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ & Bellen HJ (2007) Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol 178, 309-322. https://doi.org/10.1083/jcb.200701030
Evergren E, Gad H, Walther K, Sundborger A, Tomilin N & Shupliakov O (2007) Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse. J Neurosci 27, 379-390. https://doi.org/10.1523/jneurosci.4683-06.2007
Evergren E, Zotova E, Brodin L & Shupliakov O (2006) Differential efficiency of the endocytic machinery in tonic and phasic synapses. Neuroscience 141, 123-131. https://doi.org/10.1016/j.neuroscience.2006.03.038
Lengqvist J, Svensson R, Evergren E, Morgenstern R & Griffiths WJ (2004) Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry. J Biol Chem 279, 13311-13316. https://doi.org/10.1074/jbc.m310958200
Evergren E, Tomilin N, Vasylieva E, Sergeeva V, Bloom O, Gad H, Capani F & Shupliakov O (2004) A pre-embedding immunogold approach for detection of synaptic endocytic proteins in situ. J Neurosci Methods 135, 169-174. https://doi.org/10.1016/j.jneumeth.2003.12.010
Evergren E, Marcucci M, Tomilin N, Löw P, Slepnev V, Andersson F, Gad H, Brodin L, De Camilli P & Shupliakov O (2004) Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse. Traffic 5, 514-528. https://doi.org/10.1111/j.1398-9219.2004.00198.x
Bloom O, Evergren E, Tomilin N, Kjaerulff O, Löw P, Brodin L, Pieribone VA, Greengard P & Shupliakov O (2003) Colocalization of synapsin and actin during synaptic vesicle recycling. J Cell Biol 161, 737-747. https://doi.org/10.1083/jcb.200212140
Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D & Chaiken IM (2002) Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes. Anal Biochem 307, 258-265.